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Treatment with FOXO4-DRI significantly reduced SA-beta-gal staining (a senescence marker) and decreased senescence-associated secretory factor expression

Poly-L-lysine (polylysine) and poly-L-glutamic acid (polyglutamic acid) have long been used as models for the spectroscopic identification of secondary structure sequences in proteins since, being disordered at neutral pH, they adopt well-defined conformations under certain conditions of temperature and pH (Yu and Krimm, 1977)

Several conventional treatments, such as pharmacological, non-pharmacological, surgery, and emerging and experimental approaches, are available for treating PD (10)